Dr.Drop – 13Lives

BCP (β-Caryophyllene) – 375mg/mL
Myrcene – 250mg/mL
BCP + Myrcene: The Synergistic Duo

What is BCP?

β-Caryophyllene (BCP) is a non-psychoactive cannabinoid and a full agonist of the CB2 receptor.

• Unlike CBD, which is only a partial agonist, BCP fully activates CB2.

• Found naturally in essential oils of many plants.

Natural Sources of BCP

(References: Ahmed et al. 2000; Alma et al. 2007; Bernotienë et al. 2004; Calvo-Irabien et al. 2009; Jirovetz et al. 2002; Kaul et al. 2003; Leandro et al. 2012; Prashar et al. 2004; Ormeño et al. 2008; Silva et al. 2004; Singh et al. 2006; Vito & Steinemann 1997)

• Marijuana flower – 37.5%

• Copaiba – 35%

• Malabrathum – 25.3%

• Basil – 19.8%

• Clove bud – 19.5%

• Oregano – 15.7%

• Hops – 14.5%

• True cinnamon – 11.1%

• Ylang-ylang – 10.7%

• Rosemary – 8.3%

• Black caraway – 7.8%

• Lavender – 7.55%

• Black pepper – 7.29%

What is Myrcene?

Myrcene is a terpene commonly found in cannabis, hops, and lemongrass. Known for its relaxing, anti-inflammatory, and analgesic effects, it enhances cell permeability, allowing other compounds (like BCP) to act more effectively.

Reported Benefits of Myrcene

(References: Russo 2011; Rufino et al. 2015; Hartsel et al. 2016)

• Natural sedative and muscle relaxant

• Supports pain relief and inflammation reduction

• Enhances the “entourage effect” with cannabinoids

• May support sleep quality and recovery

• Shown to work synergistically with BCP and other terpenes

BCP & CB2 – Therapeutic Potential

(References: Bahi et al. 2014; Basha & Sankaranarayanan 2014; Bento et al. 2011; Calleja et al. 2013; Chang et al. 2013; Cheng et al. 2014; Gertsch 2008; Hartsel et al. 2016; Mahmoud et al. 2014; Rufino et al. 2015)

Research highlights BCP’s potential in supporting:

• Inflammation & pain relief

• Atherosclerosis & cardiovascular health

• Osteoporosis & osteoarthritis

• Colitis & digestive health

• Diabetes management

• Cerebral ischemia (stroke recovery)

• Anxiety & depression

• Liver fibrosis

• Alzheimer-like conditions

Cancer Research (Legault & Pichette 2007)

• Synergy with chemotherapy drug Paclitaxel

• Promotes apoptosis (healthy cell death cycle)

• Suppresses tumor growth

BCP vs. CBD

The Ki value measures receptor affinity (lower = stronger).

• BCP (Ki = 320nM) → requires 11x less compound than CBD to activate CB2

• CBD (Ki = 2860nM) → weaker binding to CB2

✅ BCP fully activates 100% of CB2 receptors
❌ CBD activates only ~60%

Conclusion: BCP is far more potent and effective than CBD for CB2 activation.

Pharmacokinetics & Pharmacodynamics

• • Oral BCP showed greater pain relief than synthetic CB2 agonist JWH-133 (Klaukea et al. 2013).

  • BCP Half-life: 3.5 hours (Poddighe et al. 2018).

  • Myrcene: Rapidly absorbed, contributes to permeability enhancement and synergy with other cannabinoids.

References

Abcam. 2019. (-)-Cannabidiol, Natural cannabinoid (ab120448). Retrieved from https://www.abcam.com/--cannabidiol-natural-cannabinoid-ab120448.html#top-41

Ahmed, A., Choudhary, M. I., Farooq, A., Demirci, B. & Başer, H. C. 2000. Essential oil constituents of the spice Cinnamomum tamala (Ham.) Nees & Eberm. Flavour and Fragrance Journal, 15(6), pp. 388-390

Alma, M. H., Ertaş, M., Nitz, S. & Kollmannsberger, H. 2007. Chemical composition and content of essential oil from the bud of cultivated Turkish clove. BioResources, 2(2), pp. 265-269.

Atakan, Z. 2012. Cannabis, a complex plant: different compounds and different effects on individuals. Therapeutic Advances in Psychopharmacology, 2(6), pp. 241-254.

Bahi, A., Al Mansouri, S., Al Memari, E., Al Ameri, M., Nurulain, S. M. & Ojha, S. 2014. β-Caryophyllene, a CB2 receptor agonist produces multiple behavioral changes relevant to anxiety and depression in mice. Physiology & Behaviour, 135, pp. 119-124.

Basha, R. H. & Sankaranarayanan, C. 2014. β-Caryophyllene modulates carbohydrate metabolism in diabetic rats. Acta Histochemica, 116(8), pp. 1469-1479.

Bento, A. F., Marcon, R., Dutra, R. C., Claudino, R. F., Cola, M., Leite, D. F. & Calixto, J. B. 2011. β-Caryophyllene inhibits colitis in mice through CB2 receptor activation. The American Journal of Pathology, 178(3), pp. 1153-1166.

Bernotienë, G., Nivinskienë, O., Butkienë, R. & Mockutë, D. 2004. Chemical composition of essential oils of hops (Humulus lupulus L.). Chemija, 2(4), pp. 31-36.

Calleja, M. A., Vieites, J. M., Montero-Meléndez, T., Torres, M. I., Faus, M. J., Gil, A. & Suárez, A. 2013. Antioxidant effect of β-caryophyllene protects rat liver from fibrosis. British Journal of Nutrition, 109(3), pp. 394-401.

Calvo-Irabien, L. M., Yam-Puc, J. A., Dzib, G., Escalante-Erosa, F. & Peña-Rodriguez, L. M. 2009. Effect of postharvest drying on Mexican oregano essential oil. Journal of Herbs, Spices & Medicinal Plants, 15(3), pp. 281-287.

Chang, H. J., Kim, J. M., Lee, J. C., Kim, W. K. & Chun, H. S. 2013. Protective effect of β-caryophyllene against cerebral ischemia. Journal of Medical Food, 16(6), pp. 471-480.

Cheng, X. R., Zhou, W. X. & Zhang, Y. X. 2014. Alzheimer’s disease animal model features. Ageing Research Reviews, 13, pp. 13-17.

Gertsch, J. 2008. Anti-inflammatory cannabinoids in diet. Communicative & Integrative Biology, 1(1), pp. 26-28.

Gertsch, J., Leonti, M., Raduner, S., Racz, I., Chen, J. Z., Xie, X. Q., Altmann, K. H., Karsak, H. & Zimmer, A. 2008. Beta-caryophyllene is a dietary cannabinoid. PNAS, 105(26), pp. 9099-9104.

Hartsel, J. A., Hades, J., Hickory, B. & Makriyannis, A. 2016. Cannabis sativa and Hemp. In: Nutraceuticals, pp. 735-754.

Jirovetz, L., Buchbauer, G., Ngassoum, M. B., Geissler, M. 2002. Aroma analysis of Piper nigrum oils. Journal of Chromatography A, 976(1-2), pp. 265-275.

Kaul, P. N., Bhattacharya, A. K., Rao, B. R., Syamasundar, K. V. & Ramesh, S. 2003. Essential oils from cinnamon parts. Journal of the Science of Food and Agriculture, 83(1), pp. 53-55.

Klaukea, A. L., Racza, I., Pradiera, B., Markerta, A., Zimmera, A. M., Gertschb, J. & Zimmer, A. 2013. β-caryophyllene exerts analgesic effects. European Neuropsychopharmacology, 24(4), pp. 608-620.

Leandro, L. M., Vargas, F. de S., Barbosa, P. C., Neves, J. K., Da Silva, J. A. & Da Veiga-Junior, V. F. 2012. Chemistry and biological activities of terpenoids from copaiba. Molecules, 17(4), pp. 3866-3889.

Legault, A. & Pichette, J. 2007. Potentiating effect of beta-caryophyllene on anticancer activity. Journal of Pharmacy and Pharmacology, 59(12), pp. 1643-1647.

Mackie, K. 2006. Cannabinoid receptors as therapeutic targets. Annual Review of Pharmacology and Toxicology, 46, pp. 101-122.

Mahmoud, M. F., Swefy, S. E., Hasan, R. A. & Ibrahim, A. 2014. Role of cannabinoid receptors in hepatic fibrosis. European Journal of Pharmacology, 742, pp. 118-124.

Ormeño, E., Baldy, V., Ballini, C. & Fernandez, C. 2008. Diversity of volatile terpenes from plants. Journal of Chemical Ecology, 34(9), pp. 1219-1229.

Prashar, A., Locke, I. C. & Evans, C. S. 2004. Cytotoxicity of lavender oil. Cell Proliferation, 37(3), pp. 221-229.

Poddighe, L., Carta, G., Serra, M. P., Melis, T., Boi, M., Lisai, S., Murru, E., Muredda, L., Collu, M., Banni, S. & Quartu, M. 2018. β-caryophyllene prevents endocannabinoid activation during carotid occlusion. Lipids in Health and Disease, 17, pp. 23.

Rufino, A. T., Ribeiro, M., Sousa, C., Judas, F., Salgueiro, L., Cavaleiro, C. & Mendes, A. F. 2015. Anti-inflammatory, anti-catabolic, and pro-anabolic effects of terpenes. European Journal of Pharmacology, 750, pp. 141-150.

Russo, E. B. 2011. Taming THC: cannabis synergy and entourage effects. British Journal of Pharmacology, 163(7), pp. 1344-1364.

Silva, M. G. de V., Matos, F. J. de A., Lopes, P. R. O., Silva, F. O. & Holanda, M. T. 2004. Composition of Ocimum oils. Arkivoc, (vi), pp. 66-71.

Singh, G., Marimuthu, P., de Heluani, C. S. & Catalan, C. A. 2006. Antioxidant and biocidal activities of Carum nigrum essential oil. Journal of Agriculture and Food Chemistry, 54(1): 174–81.

Vito, M. & Steinemann, S. 1997. Essential oil of Cannabis sativa strains. International Hemp Association, 4(2), pp. 80-82.

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